BME432 Biocompatibility
Course Objective: To understand the fundamentals of biological performance of materials used in regenerative engineering and medical devices.
Instructor: Cevat Erişken, Ph.D., Department of Biomedical Engineering, Office 175/5, Tel 0(312)-292-4083, cerisken@etu.edu.tr, http://cerisken.etu.edu.tr
TA: Ece Bayrak, Technology Center, Tissue Engineering Lab 201, Tel 0(312)-292-4579, ece.bayrak08@gmail.com
Textbook: Biocompatibility and performance of medical devices, 2012, Edited by J-P Boutrand
Course Description: This course is designed to motivate student learning in the field of biocompatibility, with emphasis on understanding the ability of a material to perform with an appropriate host response in a specific situation. Biocompatibility covers the host responses to biomaterials and medical devices as well as the responses of these to physiological conditions.
Therefore, cell-material interactions and the underlying mechanisms define the basics of biocompatibility. The variables that could influence the host response could be, but are not limited to, material composition, structure, morphology, crystallinity, porosity and surface chemical composition. The problems that may arise with the exposure of materials to the human body may include undesired accumulation of proteins and cells, granulation tissue formation, immune cell responses, tumor formation material degradation leading to failure.
Grading: Mid-term : 30% Quizzes : 15% Presentation & Discussions : 15% Final : 40%
Week 1-2 — Introduction, Challenges & failure in biomaterials Week 3 — Biomechanical and biochemical compatibility Week 4 — In vitro and in vivo testing for biological safety Week 5 — Compatibility of blood contacting materials Week 6 — Dental implants Week 7 — Bone implants Book copy — How the immune system works - Reading (Lectures 1-7 inclusive) Week 8 — Soft Tissue grafts Week 9 — Immune system Week 10 — Biocompatibility of carbon nanotubes Final exam — Final exam essay and grading scheme
Presentation Groups (Presentation template):
1) 24 May 2016 (Dental implants): Elif Ateş
2) 31 May 2016 (Knee replacement): Meriç Göker
3) 7 June 2016 (Ocular implants): Buşra Özlü
4) 14 June 2016 (ACL grafts): Aybüke Demirbilek
5) 21 June 2016 (Hip replacement): Enis Taha Özkan
6) 28 June 2016 (Heart valves): M. Gül Şakı
7) 5 Jul 2016 (Cranial implants): Mertcan Özdemir
8) 12 Jul 2016 (IV discs): Sevcan Budak
9) 19 Jul 2016 (Pacemaker): Beyza N Susam
10) 26 Jul 2016 (Sutures): Elif Çiğdem Türk |
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Cevat Erisken, Ph.D. |
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TOBB University of Economics and Technology, Biomedical Engineering Department |
